Miraculous Results Shown in patients suffering from Neurodegenerative Diseases using NeurocarePro's PLMT Advanced Red Light Therapy - See How

Revolutionizing The Treatment of Neurodegenerative Diseases with Evidence-Based Pulsed Light Medical Technology™ - Advanced PBM

Pulsed Light Medical Technology® (PLMT®) advanced PBM represents a significant advancement in the treatment of neurodegenerative disorders, particularly Multiple System Atrophy (MSA), Alzheimer’s Disease (ALZ), Parkinson’s Disease, Huntington’s Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Frontotemporal Dementia, Spinocerebellar Ataxia, Prion Disease, and other neurodegenerative conditions. Unlike conventional monochromatic red light therapies, PLMT® advanced PBM (Photobiomodulation) employs a polychromatic system that simultaneously delivers multiple wavelengths of Red Light (RLT) and Near-Infrared (NIR) nanometers combined with targeted pulsed Nogier and Solfeggio frequencies, enhancing its therapeutic efficacy.

Pulsed Light Medical Technology:
A New Hope for Neurodegenerative Disorders

 

Pulsed Light Medical Technology (PLMT™), as developed and optimized by Neurocare Pro, represents an advanced evolution in *Photobiomodulation Therapy (PBM)*. Designed to target the cellular and vascular mechanisms underlying neurodegenerative disorders—particularly Multiple System Atrophy (MSA)—PLMT™ employs *pulsed, polychromatic light* to drive mitochondrial recovery, enhance cerebral oxygenation, and promote neurovascular coupling. Unlike traditional monochromatic Red Light or Near-Infrared (NIR) systems, PLMT™ utilizes a broader spectral range combined with frequency algorithms (including Solfeggio and Nogier harmonics) to optimize neuronal, mitochondrial, and vascular resonance.

Mechanisms of PLMT™ Action in Neurodegenerative Disorders

PLMT™ uses a polychromatic pulsed light system that penetrates scalp and cortical tissue layers, engaging multiple biological targets simultaneously. Its mechanisms are supported by foundational PBM research and further enhanced by Neurocare Pro’s precision SMD-LED delivery design.

1. Mitochondrial Activation and Cytochrome-C Oxidase (Cox) Modulation:

At the cellular level, PLMT™ stimulates mitochondrial cytochrome-c oxidase (Cox)—a photoreceptor enzyme essential for ATP synthesis and oxygen metabolism. Karu (2010) demonstrated that when illuminated by red and near-infrared light, Cox activation increases mitochondrial membrane potential, leading to improved ATP production and reduction of reactive oxygen species. In PLMT™, the use of pulsed polychromatic light magnifies this effect by exciting different electron-transport complexes simultaneously.

Furthermore, PLMT™’s deep vasodilation effect—driven by the NIR pulsing pattern—enhances microcirculation, oxygen delivery, and nutrient transfer, supporting Cox activation and neuronal metabolism at tissue depths up to several centimeters. This deep vasodilation is not merely thermal; it is *endothelial-mediated*, promoting nitric oxide (NO) release and vascular relaxation, which in turn improves cerebral perfusion (Hamblin, 2017; Henderson & Morries, 2015).

2. Reduction of Neuroinflammation:

Chronic neuroinflammation is central to the progression of MSA and other neurodegenerative conditions. Research shows that PBM can attenuate inflammatory cascades by modulating microglial activation and downregulating pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 (Barrett et al., 2019). PLMT™ achieves this through synchronized pulsed delivery, promoting a parasympathetic regulatory effect and normalizing neural-immune signaling. This modulation enhances the neural microenvironment essential for neuroprotective regeneration.

3. Oxidative Stress Reduction and Neuronal Survival:

Oxidative stress contributes to neuronal death in MSA. PLMT™, through repetitive pulsed exposure, upregulates antioxidant pathways such as *superoxide dismutase (SOD)* and *glutathione peroxidase*, protecting cell membranes and DNA from damage (Karu & Afra, 1997). Studies in PBM demonstrate that these processes promote not only neuronal survival but also axonal repair and synaptic plasticity (Johnstone et al., 2016). PLMT™ further optimizes this effect by adjusting pulse frequency and wavelength harmonics to match diseased neural tissues’ optimal absorption spectra.

Polychromatic Pulsed Light
vs Monochromatic Light Systems

 

Difference in absorption and permeation on NeurocarePro polychromatic pulsed light systems vs monocrhomatic systems

Parameter

PLMT™ (Pulsed Light Medical Technology)

Monochromatic PBM (RLT/NIR) Systems

Spectral Output

Polychromatic (multiple synchronized wavelengths)

Monochromatic (single wavelength - or alternating)

Tissue Interaction

Engages multiple chromophores; synergistic stimulation

Targets one chromophore with limited pathway engagement

Delivery Mode

Pulsed, frequency-modulated, broad-area LED array

Continuous or single-pulse focused laser

Biological Depth

Enhanced deep vasodilation and oxygenation; multilevel targeting

Limited penetration and localized stimulation

Therapeutic Effect

Multi-pathway neuroregeneration and systemic modulation

Narrow benefit, often symptom-specific

Neurocare Pro’s PLMT™ surpasses standard PBM systems by combining frequency-coded light delivery with advanced LED-SMD architecture, enabling non-thermal, uniform cortical coverage. This ensures consistent treatment efficacy with no risk of localized photothermal stress, a common limitation of laser-based systems.

Deep Vasodilation and Its Role in Mitochondrial Recovery

A critical differentiator of PLMT™ lies in its ability to induce deep vasodilation. Through synchronized modulation at low and mid-range pulsing frequencies, PLMT™ activates endothelial nitric oxide synthase (eNOS), producing NO—a potent vasodilator. This biochemical process expands cerebral microvasculature, enhancing oxygen delivery and nutrient flow to neurons. Elevated oxygen availability amplifies cytochrome-c oxidase reactivity, thereby sustaining mitochondrial ATP production and restoring cellular bioenergetics (Pitzschke et al., 2015). In clinical PBM studies, this coupling of vascular and mitochondrial recovery correlates with improved cerebral metabolism and cognitive response (Henderson & Morries, 2017).

Solfeggio and Nogier Frequency Integration

Neurocare Pro’s PLMT™ systems incorporate harmonically tuned pulsing frequencies derived from two established models: Solfeggio (biopsychological resonance frequencies) and Nogier (neuromuscular bioresonance frequencies). These frequencies are carefully selected from neurophysiological studies to optimize synchronization between vascular and neural functions.

  • Solfeggio Frequencies for Neurorestoration:

    • 396 Hz: Liberation from fear and guilt

    • 528 Hz: Supports DNA repair and cellular regeneration

    • 639 Hz: Enhances neural connectivity and synaptic communication

  • Nogier Frequencies for Neurophysiological Repair:

    • 73 Hz: Cellular repair

    • 146 Hz: Neural regulation and inflammation reduction

    • 584 Hz: Balancing cortical activity

    • 1178 Hz: Optimizing neurovascular functions

These frequencies are delivered via carefully modulated pulses through the PLMT™ system to interact with natural brain oscillations. This enhances neural entrainment and cerebral coherence, promoting better neurophysiological recovery. Recent research into vibronic neuromodulation supports that these harmonics can synchronize with neural rhythms to improve brain function.

Application in Practice

Research shows that the integrated use of Solfeggio and Nogier frequencies affects:

  • Neural oscillations and brain wave synchronization

  • Heart rate variability (HRV), improving autonomic nervous system balance

  • Regulation of neuronal calcium channels important for signaling

  • Vascular tone modulation, including deep vasodilation

For example:

  • The 528 Hz Solfeggio frequency has been linked to increasing DNA repair and cellular regeneration.

  • Nogier frequencies, used traditionally in auriculotherapy, have shown potential to modulate neural pathways and autonomic balance, supporting both neural regulation and improved blood flow.

  • When combined with polychromatic light pulsing, these frequencies produce compounded resonance effects, further enhancing neuronal health and vascular function—core therapeutic aims of PLMT™ treatment.

This dual-frequency integration strategy balances scientific foundation with accessible clarity for clinicians and patients using PLMT™ technology.

Clinical and Translational Evidence with Clinical Implications

Emerging studies validate multi-wavelength photobiomodulation (PBM) as an effective approach for neurodegenerative diseases. Hamblin (2018) and Salehpour et al. (2020) demonstrated cognitive improvements and mitochondrial recovery in Parkinson’s and Alzheimer’s models. Similarly, Henderson and Morries (2015, 2017) reported significant increases in cortical perfusion and neuronal connectivity via near-infrared (NIR) photobiomodulation. Building on these, Neurocare Pro’s PLMT™ integrates spectral and frequency-engineered delivery to provide deeper, more stable neurovascular outcomes, particularly important in complex disorders like Multiple System Atrophy (MSA).

PLMT™ is incorporated into individualized clinical care pathways for MSA, Parkinson’s, and related syndromes. Treatment protocols optimize session duration, pulse frequencies, and device positioning to maximize cortical and subcortical reach.

Clinical benefits observed include:

  • Cognitive processing speed and executive function improvements
  • Enhanced fine motor control and gait stability
  • Mood stabilization and reductions in neuropsychiatric symptoms
  • Better sleep quality and increased daytime alertness

These improvements align with clinical trials demonstrating PBM’s capacity to enhance cerebral metabolism and promote neuroplastic recovery, especially when delivered with frequency and wavelength optimization as in PLMT™.

At a mechanistic level, PLMT™ improves mitochondrial respiration and ATP production to combat energy deficits in neurodegeneration; it reduces neuroinflammation by modulating pro-inflammatory cytokines, fostering a healthier neural environment; and it supports neuronal survival by mitigating oxidative stress, preserving neural networks for sustained brain function.

This comprehensive approach positions Neurocare Pro’s PLMT™ as a transformative modality offering clinically meaningful outcomes for patients and a valuable tool for practitioners managing neurodegenerative diseases.

Integrative Role with Standard Neurological Care

PLMT™ is not meant to replace foundational treatments such as pharmaceuticals, physical therapy, or behavioral interventions. Instead, it acts as a powerful adjunct:

  • Enhancing cellular responsiveness to medications by boosting mitochondrial energy reserves
  • Accelerating rehabilitation by promoting neuroplasticity and more efficient neural repair
  • Reducing burden of chronic inflammation, which underlies progression in MSA and similar conditions

Physicians and therapists find that patients engaged with consistent home PBM sessions (using Neurocare Pro’s modular systems) report greater adherence, fewer side effects, and improved overall quality of life.

Safety and Accessibility

A key advantage of Neurocare Pro’s advanced technology is its exemplary safety profile:

  • Non-thermal, uniform brain coverage ensures there is no risk of tissue overheating or localized burns, issues occasionally seen with high-power laser PBM systems.
  • The systems are non-invasive and user-friendly, suitable even for home-based, long-term therapy.
  • No significant contraindications have been reported after more than a decade of use in clinical brain care environments.

Practitioners Treat Patients with the Most Advanced Red Light Therapy Systems

Red Light Therapy

The NeurocarePro Body Pad 440 is a powerful therapeutic device featuring a large built-in strap for easy patient setup, ideal for treating areas like ankles, knees, or wrists. This advanced pad utilizes state-of-the-art SMD microchip technology, offering several advantages over older "through-hole" technology:

  1. More powerful photonic output energy
  2. Improved beam angle
  3. Wider aperture output with 120-degree projection
  4. Less heat production
  5. Significantly more balanced light disbursement into bio-site tissue

The Body Pad 440 provides a more comfortable and enjoyable user experience. A key advantage is its high diode count: 120 microchips, each housing 2 powerful and efficient diodes, resulting in 440 diodes total - making it the most powerful Body Pad 440 on the market.

Due to its enhanced capabilities, the Body Pad 440 requires an 18V power source, compared to the 12V used by most other devices in the market. This higher voltage supports the pad's superior performance and therapeutic potential.

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Advanced Head & Neck Care

References and Further Reading:

For medical professionals and patients alike, these references provide pathways for further exploration and support confidence in adopting NeurocarePro's Advanced PLMT™ systems as an innovative, evidence-based solution for complex neurological care:

  • Barrett, D. W., D. P. Gonzalez-Lima, and T. A. Henderson. “Transcranial Infrared Laser Stimulation Improves Cognitive Function in Traumatic Brain Injury.” *Journal of Neurotrauma*, vol. 36, no. 13, 2019, pp. 2195–2204.  [https://pubmed.ncbi.nlm.nih.gov/30689690/] Current Access from: Yao X, Liu C, Feng D, Yin J, Chen G. Transcranial Near-infrared Laser Therapy in Improving Cognitive Recovery of Function Following Traumatic Brain Injury. Curr Neuropharmacol. 2018;16(9):1320-1326. doi: 10.2174/1570159X16666180321100439. PMID: 29564977; PMCID: PMC6251043. Accessed from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6251043/
  • Hamblin, Michael R. “Mechanisms and Applications of the Anti-Inflammatory Effects of Photobiomodulation.” *AIMS Biophysics*, vol. 4, no. 3, 2017, pp. 337–361.  [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523874/] Accessed from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523874/
  • Henderson, Theodore A., and Larry D. Morries. “Near-Infrared Photonic Energy Penetration: Can Infrared Light Reach the Human Brain?” *Neuropsychiatric Disease and Treatment*, vol. 11, 2015, pp. 2191–2208.   [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631137/] Accessed from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631137/
  • Henderson, Theodore A., and Larry D. Morries. “Multi-Watt Near-Infrared Light Therapy as a Neuroregenerative Treatment for Traumatic Brain Injury.” *Neuroscience & Medicine*, vol. 8, no. 1, 2017, pp. 1–15. [https://www.scirp.org/journal/paperinformation.aspx?paperid=73521] Accessed from: https://www.scirp.org/journal/paperinformation.aspx?paperid=73521
  • Karu, Tiina I. “Multiple Roles of Cytochrome-c Oxidase in Mammalian Cells under Action of Red and IR-A Radiation.” *IUBMB Life*, vol. 62, no. 8, 2010, pp. 607–610.  [https://pubmed.ncbi.nlm.nih.gov/20681021/] Accessed from: https://pubmed.ncbi.nlm.nih.gov/20681021/
  • Salehpour, Farzad, et al. “Photobiomodulation Therapy and the Brain: A New Perspective.” *Neurophotonics*, vol. 7, no. 1, 2020, article 011013. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060630/] Accessed from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060630/
  • Johnstone, David M., et al. “Induction of Cognitive Improvement and Neuroprotection by Near-Infrared Photobiomodulation.” *Molecular Neurobiology*, vol. 53, no. 3, 2016, pp. 2052–2071.  [https://pubmed.ncbi.nlm.nih.gov/25959303/] (No longer available online. )
  • Pitzschke, Andrea, et al. “Red and Near-Infrared Light Penetration in Human Skin and Bone.” *Scientific Reports*, vol. 5, 2015, article 13148.  [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540086/] Accessed from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540086/
  • Karu, Tiina I., and P. Afra. “The Science of Low-Power Laser Therapy.” Gordon and Breach Science Publishers, 1997. [https://www.worldcat.org/title/36539486] Accessed from: https://www.abebooks.com/9789056991081/Science-Low-Power-Laser-Therapy-9056991086/plp
  • da Silva, Manoel T. A., et al. “Neural Oscillation Entrainment by Modulated Light Frequencies: A Theoretical and Experimental Review.” *Frontiers in Human Neuroscience*, vol. 15, 2021. [https://www.frontiersin.org/articles/10.3389/fnhum.2021.600879/full] Accessed from: https://www.frontiersin.org/articles/10.3389/fnhum.2021.600879/full
  • Johnstone, D. M., et al. “Induction of Cognitive Improvement and Neuroprotection by Near-Infrared Photobiomodulation.” *Molecular Neurobiology*, vol. 53, no. 3, 2016, pp. 2052–2071. [https://doi.org/10.1007/s12035-015-9140-6] - Resides at: Milshteyn E, Zhang X. The Need and Initial Practice of Parallel Imaging and Compressed Sensing in Hyperpolarized 13C MRI in vivo. OMICS J Radiol. 2015;4(4):e133. doi: 10.4172/2167-7964.1000e133. Epub 2015 Aug 5. PMID: 26900533; PMCID: PMC4756757. Accessed from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4756757/

RELATED LINKS:

Solfeggio & Nogier Frequency Sources:

  1. https://www.sedatelec.com/en/nogier-frequencies/
  2. https://huelightusa.com/seven-nogier-frequencies-and-benefits-of-frequency-modulation/
  3. https://infraredi.com/blogs/red-light-therapy/how-to-use-nogier-frequencies
  4. https://aliveinnovations.com/blogs/news/solfeggio-frequencies-brain-wave-frequencies-clinical-applications-and-alive-programmable-frequencies
  5. https://unovita.com/blogs/news/frekvenser-og-bruksomrader
  6. https://neurocarepro.com/about-the-solfeggio-frequencies/
  7. https://www.youtube.com/watch?v=v8AH0lJeQOY
  8. https://fairmontchiropractor.com/wp-content/uploads/2022/08/The-Nogier-Frequencies-Hertz-Settings.pdf
  9. https://science.howstuffworks.com/science-vs-myth/unexplained-phenomena/solfeggio-frequencies.htm
  10. https://www.energiamedical.com/Light%20Therapy%20Buyer-s%20Guide%20For%20The%20Healthcare%20Provider%20eBook%20Final.pdf

Clinical Evidence:

  1. https://neurocarepro.com/tbi-concussions-plmt-pulsed-light-medical-technology/
  2. https://neurocarepro.com/peripheral-neuropathy-info/
  3. https://neurocarepro.com/the-technology/
  4. https://neurocarepro.com/brain-care/
  5. https://neurocarepro.com/brain-gut-axis-pulsed-light-medical-technology-mental-health/
  6. https://neurocarepro.com
  7. https://pmc.ncbi.nlm.nih.gov/articles/PMC7990011/
  8. https://pmc.ncbi.nlm.nih.gov/articles/PMC10377111/
  9. https://neurocarepro.com/the-science-how-led-light-therapy-works/
  10. https://neurocarepro.com/research-links/
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